Drostanolone propionate: estrogen and androgen action

Pharmacological group: anabolic / androgenic steroids

Androgen: 25-40

Anabolic: 62-130

Standard: Testosterone

Chemical name: 2alpha-methyl-androstan-3-one-17beta-ol 2alpha-methyl-dihydrotestosterone

Estrogenic Activity: none

Progesterone Activity: unknown (low)

Description

Drostanolone propionateinjecting anabolic steroid based dihydrotestosterone (DHT). It has a modified base DHT. 2-methyl group increases the anabolic properties of the drug and its effectiveness to promote the growth of muscle tissue, as compared with its unmethylated precursors. Drostanolone propionate is described in the literature as “steroid with potent anabolic and anti-estrogenic properties.” However, its anabolic properties properly called moderate, especially when compared with other drugs. The drug most frequently used by bodybuilders during a diet and athletes in speed sports, where it is prized for its ability to increase muscle mass and strength that is usually accompanied by a decrease in the level of fat and minimal side effects.

History

Drostanolone propionatebuy drostanolone propionat was first described in 1959. Syntex Company has developed along with the drug commonly known steroids such as Anapolon and Metildrostanolon (superdrol), first described in the same time. About ten years later, drostanolone propionate begins to be used as a prescription drug. , Lilly entered into an agreement with Syntex separation of duties for certain research and development in exchange for the right to sell the results of this study. Lilly, thus gaining the right to sell drostanolone propionate in the United States under the brand name Drolban, and the company Syntex – in other markets. These products include, inter alia, in Belgium Masteron (SarvaSyntex) and Portugal (Cilag), Masteril in the UK and Bulgaria, and Metormon in Spain. Drostanolone propionate is also a member of such popular products as Permastril (Cassenne, France), Mastisol (Shionogi, Japan) and Masterid (Grunenthal, the German Democratic Republic). The US Department of quality control of food and drugs (FDA) approved drostanolone propionate for the treatment of inoperable breast cancer in postmenopausal women. This fact influenced the clinical indications for the drug in all international markets. The medical literature is often stated that drostanolone propionate has a much smaller effect virilization in comparison with equal doses of testosterone propionate, and is considered a good alternative to injection of testosterone to women. However, this dose level (300 mg weekly) is relatively high. Before the drug can appear mild symptoms of virilization, such as deepening of the voice, acne, facial hair growth, and clitoral enlargement. It is also noted that the effects of virilization sometimes occurs after a period of prolonged therapy. Very popular among athletes in the 1970s and 80s, drostanolone propionate and enjoyed limited success as a prescription drug. Manufacturers soon voluntarily stopped sales of the drug in different markets, which is probably due to the emergence of more effective treatments for breast cancer, as well as a gradual decline in popularity of steroids at this stage of treatment. One of the first drugs that ceased to exist on the market, was Drolban in the US is no longer available in the late 1980s. Soon it was followed Permastril and Metormon. The last remaining West preparation containing drostanolone propionate – drug Masteron from Belgium, disappeared from the market in the late 1990s. Drostanolone propionate is still in the US Pharmacopoeia and it is estimated that currently there are no legal obstacles to its implementation, although commercial rebirth Masteron as a prescription drug is highly unlikely.

How Supplied

Drostanolone propionate is no longer available as a prescription drug. During its production the drug was produced in the form of 1 ml and 2 ml vials and 10 ml vials containing 50 mg / ml or 100 mg / ml of the steroid in the oil.

Structural Features

Drostanolone (also known as dromostanolone) is a modified form of dihydrotestosterone. It is characterized by the introduction of a methyl group at carbon-2 (alpha), which significantly increases the anabolic steroid effect and enhances its stability to metabolism in the skeletal muscle tissues through the 3-hydroxysteroid dehydrogenase enzyme. Drostanolone propionate is a modified form of drostanolone, wherein the carboxylic acid (propionic acid) is attached to the 17-beta hydroxy group. Esterified steroids are less polar than the free steroid and slowly absorbed from the injection site. Once in the blood, the air is removed, leaving the free (active) drostanolone. Esterified steroids are designed to prolong the therapeutic effect after the reception, which allows you to inject less frequently than with the free (non-esterified) steroids. The half-life drostanolone propionate lasts about two days after the injection.

Side effects Masteron (estrogen)

Drostanolone is not flavored, nor is markedly estrogenic substance. In the application of this steroid it is not necessary to use an anti-estrogen and gynecomastia are usually not evident even in very sensitive individuals. Drostanolone provides user-dried and “quality” in the form of body, without excess subcutaneous fluid retention. This makes it a favorable steroid to use during drying, when water and fat retention are major challenges. As nearomatiziruemoe DHT derivative, drostanolone may have anti-estrogenic effect, and compete with other (flavoring) substrates in the binding of the enzyme aromatase.

84Side effects Masteron (androgens)

Although the drug is classified as an anabolic steroid, when the reception is still possible manifestation androgenic side effects, especially at higher doses. It effects may include: increased fat content of the skin, acne and hair growth on the body / face. Anabolic / androgenic steroids may also aggravate male pattern baldness. Women also need to be warned of the potential virilizing effects of anabolic / androgenic steroids. These effects may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Drostanolone – steroid with relatively low androgenic activity binding in tissues, and the threshold for strong androgenic side effects, it has a relatively higher as compared with more androgenic agents such as testosterone or fluoxymesterone methandrostenolone. Note that drostanolone does not affect the enzyme 5-alpha-reductase, so its relative androgen dependent on the simultaneous use of finasteride or dutasteride.

Side effects Masteron (hepatotoxicity)

Drostanolone is not c17-alpha alkylated substance and has no known hepatotoxic properties. Toxicity in the liver is unlikely.

Side effects Masteron (cardiovascular)

Anabolic / androgenic steroids can have deleterious effects on cholesterol levels, which includes a tendency to reduce the levels of HDL (good) cholesterol and increase LDL (bad cholesterol), HDL and biasing the ratio of LDL in the direction of fostering a greater risk of atherosclerosis. The relative impact of anabolic / androgenic steroids on serum lipids depends on the dose, routes of administration (oral or injection), a steroid-type (flavoring or less) and the level of resistance to metabolism in the liver. Drostanolone should have a stronger negative effect on hepatic cholesterol than testosterone or nandrolone, due to its non-aromatizing nature, but weaker effect than a 17-alpha alkylated steroids. Anabolic / androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, which could potentially increase the risk of cardiovascular disease and myocardial infarction. In order to reduce the risk of cardiovascular deformations, it is recommended to perform active exercises and cardio minimize the consumption of saturated fat, cholesterol, and simple carbohydrates at all times during the active use of AAS. It is also recommended additional intake of fish oil (4 g per day) and a natural cholesterol / antioxidants such as Lipid Stabil or products with comparable ingredients.

Side effects Masteron (suppression of testosterone)

All anabolic / androgenic steroids when taken in doses sufficient to promote muscle growth, inhibit the production of endogenous testosterone. Without the intervention of testosterone stimulating substances, testosterone levels should return to normal within 1-4 months of treatment. Note that secondary to steroids can develop a long hypogonadotropic hypogonadism requiring medical intervention. The above listed side effects is not complete.

Course Masteron (men)

Drostanolone propionate has not been approved by the FDA for use in men. There are no guidelines for his appointment. In order to improve the physique or performance enhancing drug is usually administered by injection three times per week. Weekly dose is generally 200-400 mg, and is received within 6-12 weeks. This dose is sufficient for a measurable increase in muscle mass and strength. To enhance the effect Drostanolone propionate is often combined with other steroids such as injectable anabolic Deca ® (nandrolone decanoate) or Equipoise ® (boldenone undecylenate), providing muscle growth without excessive water retention. For muscle building steroid is often combined with injectable testosterone. Result – muscle growth and a lower level of water retention and other estrogenic side effects than when using these steroids alone (as a rule, at higher doses). Masteron is most often used during the drying process. It is often combined with other flavoring not steroids such as Winstrol ®, Primobolan ®, Parabolan or Anavar, which helps maintain muscle mass and graft promotes fat loss, during a period which can be very catabolic without steroids.

Course Masteron (women)

Masteron women used a dose of 100 mg three times per week. Before we evaluate the effectiveness of a substance, you should take it at least 8-12 weeks. If successful, the drug can still be used as long as is necessary to obtain satisfactory results. Please note that virilization symptoms often occur even at the recommended dosage. When used in order to improve productivity or body, most often the dose of 50 mg per week for 4-6 weeks. At a dose of 100 mg per week or less masculinizing effects occur rarely. Note that because of the short nature of action ether propionate total weekly dose is usually divided into smaller injection every two or three days.

Availability:

The original Masteron is already available on the black market drug. In Europe, its production has long been discontinued. The old parties have not circulate, which means that there is no legitimate source for marketing a product called Masteron anywhere else. Other laws pharmaceutical brands are almost nonexistent. There is a version of drostanolone sold in Myanmar called Dromostan company XELOX. The preparation contains drostanolone instead drostanolone propionate. Although the drug is not passed laboratory tests, this company is legitimate and hopefully produces a legal product. If so, then this product buy liothyronine sodium is the second real Drostanolone, sold currently. Due to the absence of air, injection best done every 2 days, slightly more often than when using Masteron (3-4 times). In addition to the above, at present there are many clandestine laboratories drostanolone propionate. Make sure you understand the risks involved in the clandestine purchase of products. Risks can include more than just the loss of money as underground products are often not produced in a sterile environment.

Drostanolone propionate: main effects and features to use

Chemical structure

Drostanolone dipropionate – anabolic (known as dromostanolone) – Changes dihydrotestosterone. It differs by the addition of a methyl group at position 2alpha, which affects the strength increase anabolic steroid, increasing resistance to metabolism enzyme 3a-hydroxysteroid dehydrogenase in muscle tissue (2alpha, 5a, 17 beta) -17-Hydroxy-2-metilandrostan-3-one formula C20H32O2 . Drostanolone propionate – a modified form of drostanolone with a propionate ester attached via the 17-beta hydroxyl group. Unlike free steroids esterified less polar therefore not rapidly absorbed from the injection site. Once in the bloodstream, and the ether is cleaved by blood moves freely drostanolone. The development objective was to increase the esterified steroids during therapeutic effect after entering, to inject less frequently when compared with taking steroids available. The half-life at drostanolone propionate is about two days after injection. The medical literature drostanolone described as a powerful anabolic agent with anti-estrogenic properties. In spite of this, many scientists admit that the anabolic properties drostanola rather moderate when compared with similar drugs. It is widely used by athletes who are on a diet, as well as dealing with speed and power sports in which it is necessary to influence the property of the increase in muscle mass and strength, reducing body fat, while having no serious adverse qualities.

Historical reference

Drostanolone propionate BodybuilderDescribed drostanolone propionate was in 1959. Its development was engaged in the company Syntex, along with oksimetalonom metildrostanolonom and, despite this, in pharmacies drug appeared only 10 years later. Between the companies Lilly and Syntex was agreed on the joint application development. Drostanolone propionate first sold in the United States, calling it drolban and the second spread the same drug in other markets. In Belgium, it was called Masteron, in the UK and Bulgaria – Masters in Spain – metormon, France – permastril, Japan – mastisol in the GDR – masterid. The US by the Food and Drug Administration approved the drostanolone propionate as a drug for the treatment of inoperable breast cancer in women in menopause. That is it and used in the world. There are reports in the medical literature that drostanolone propionate gave less virilization, when compared with testosterone propionate. Despite this, in the book there is a mention that vyskokie dose (300 mg in 7 days) caused virilization. Drostanolone widely used athletes in the 70-80’s, but in medicine it was used with some restrictions. When there were other methods of treatment of breast cancer, produce drostanolone become smaller, and then completely stopped, it gradually disappeared from the market.

pharmachologic effect

It reduces the production of follicle stimulating hormone and lyuteotropnogo. Drostanolone dipropionate has androgenic (when compared to testosterone propionate, then expressed less) and anabolic (expressed more than testosterone propionate) effect. It has anti-tumor effect in patients with cancer of the thymus gland, even in the presence of metastases, and patients with suppressed ovarian function due to irradiation, androgenic drugs or undergoing ovariektomii.Effekt exercise more during a bilateral ovariectomy. Has an anabolic effect, this results in the stimulation of protein synthesis, reducing fat deposition, the delay in the human body required for protein synthesis, potassium, phosphorus, sulfur, enhancing fixation of bone calcium, and increasing muscle mass. If there is sufficient supply of protein stimulates the production of erythropoietin.

The steroid profile drostanolone dipropionate

  • Active substance is 2-3 days
  • Classification: Steroid anabolic / androgenic origin
  • Application method: by injection
  • Dosage: Men 300-500mg for 7 days; Women 25-50mg for 7 days
  • Acne: Yes
  • Water Retention: No
  • High blood pressure: Occasionally
  • Hepatotoxicity: No
  • Aromatase: No
  • Progestogenic activity: No
  • DHT (dihydrotestosterone) conversion: None
  • Decrease HPTA function (testosterone production): yes
  • Anabolic activity (25-40%); Androgenic activity (62-130%)
  • Detection time – 14 days (approximately, since doping commission is constantly looking for new and improved methods for detection of banned substances, as this depends on the athlete to use the drug, whether it uses phenobarbital and furosemide to accelerate the withdrawal of the drug)

456Effects drostanolone dipropionate

  1. It gives a good effect when used for drying
  2. It affects the density of muscle
  3. It affects performance increase strength, reducing body fat, gives a good effect when used before the competition

Application drostanolone dipropionate:

Reception (for men):

The recommended dose is equal to 300-500 mg / 7 days, usually, on the third day, or one by one. Course duration 6 (8) -10 (12) weeks. Usually combined with nandrolone decanoate or boldenone undesilinatom, it affects the increase in muscle mass, at the same time not unduly delaying the water. In order to set its weight combined with injectable testosterone, it affects the growth of muscle mass without excess “water” that would accumulate if taken with other drugs. Drostanolone is used and the purpose of “drying”. It is combined with other non-aromatizing agents, for example, stanozolol, Primobolan, trenbolone or oxandrolone, and it helps to keep the muscle on a diet and sgonke.

Reception (for women):

Women are advised to take the drug is not due to high androgen.

The medical use of drostanolone administered 100mg x 3 p in 7 days, 2-3 months, followed to evaluate the result. Signs of virilization were highly significant at this dose. In order to improve physique drug taking 25-50mg of 7 days, for 4-6 weeks. Also, it should be noted in connection with a speed of propionate ester preparation is necessary to prick every second or third day.

Side effects drostanolone dipropionate

Drostanolone does not aromatize and does not have estrogenic activity. Anti-estrogens are not needed, even sensitive people will not notice the symptoms of gynecomastia. As a general rule, estrogen retains water, but taking this steroid increases quality mass without excess liquid. In this regard, the drug was well used to the “drying”, it was then the main problem – it’s water retention and fat. As a non-aromatizing a derivative of dihydrotestosterone, drostanolone may exhibit some anti-estrogenic effect, thus competing with other substances for binding to aromatase.

Despite the fact that drostanolone is classified as an anabolic, androgenic side effects may be present. High doses of the drug can cause increased oiliness of the skin, acne, hair growth on the body and face. Anabolic steroids can probably worsen hair loss male pattern. Women should be reminded of the possible effects of AAS virilizuyuschih (deepening of the voice, irregular periods, change in skin texture, facial hair growth, and enlargement of the clitoris). Drostanolone does not react with 5a-reductase and androgen will change the parallel use of finasteride or dutasteride. While that is a steroid with low androgenic activity, its threshold androgenic side effects is much greater than that of testosterone, methandrostenolone and fluoxymesterone.

Drostanolone – not alkylated at position 17-alpha formulation in this regard it has no hepatotoxic properties.

AAS can have a detrimental effect on blood cholesterol. This may be a decrease in the level of “good” HDL cholesterol, shifting the balance towards the risk of atherosclerosis. Relative impact AAS lipids depends on the dose, route of administration, the type and level of steroid resistance hepatic metabolism. Drostanolone have a more pronounced negative effect on the control of hepatic cholesterol than testosterone and nandrolone, since it nearomatiziruyuscheyasya structure, but the effect is less than that of 17-alpha-alkylated products. AAS may adversely affect blood pressure and triglycerides, reduce endothelial relaxation of blood vessels, trigger ventricular hypertrophy, and it has the potential to increase the risk of cardiovascular disease and heart attack. To reduce the load on the cardiovascular system, it is advised to minimize the use of saturated fat, cholesterol, and simple carbohydrates during the course AAS. Recommend to use additives, such as fish oil, lipid Stabil and similar products.

All AAS doses needed to build muscle, suppress endogenous testosterone production. If you do not take testosterone stimulating substances, it will come to its normal level over 1-4 months after the course. It should be noted that prolonged hypogonadotrophic hypogonadism can develop secondary and it is likely that need medical intervention.

Indications for drug use drostanolone dipropionate

Breast cancer, including metastases in women with a menstrual cycle or stored at 5 years until menopause.

Contraindications to drug use drostanolone dipropionate

Do not take the people with the following diseases: hypersensitivity, acute liver disease, kidney disease, cardiovascular system (myocardial infarction, severe hypertension, hypertensive crisis), hypercalcemia, end-stage breast cancer.